Induction of astrocyte reactivity promotes neurodegeneration in human pluripotent stem cell models
In this article, Gomes and colleagues demonstrate the induction of a proinflammatory reactive phenotype in human pluripotent stem cell-derived astrocytes. Reactive astrocytes contributed to neurodegenerative phenotypes in multiple types of neurons, including retinal ganglion cells, cortical neurons, and motor neurons. Further, when differentiated from cell lines derived from glaucoma, Alzheimer’s disease, and ALS patient samples, the reactive state enhanced disease-associated phenotypes.
In this article, Gomes and colleagues demonstrate the induction of a proinflammatory reactive phenotype in human pluripotent stem cell-derived astrocytes. Reactive astrocytes contributed to neurodegenerative phenotypes in multiple types of neurons, including retinal ganglion cells, cortical neurons, and motor neurons. Further, when differentiated from cell lines derived from glaucoma, Alzheimer’s disease, and ALS patient samples, the reactive state enhanced disease-associated phenotypes.
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